Estimation of a common odds ratio in case-control studies of familial aggregation |
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Authors: | A Donner W Hauck |
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Affiliation: | Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada. |
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Abstract: | A new estimator of a common odds ratio is proposed for case-control studies of familial aggregation. The proposed estimator is a modification to the usual Mantel-Haenszel estimator that relies on an empirical adjustment for the within-family clustering which is typical of such designs. A simulation study shows that the estimator tends to have smaller mean squared error than the unmodified Mantel-Haenszel estimator under conditions likely to arise in practice. The construction of confidence intervals is also discussed. |
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