Degradation of Specific Nuclear Proteins Occurs in the Cytoplasm in Saccharomyces cerevisiae |
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| Authors: | Li Chen Kiran Madura |
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| Affiliation: | Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey 08854 |
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| Abstract: | The ubiquitin/proteasome system has been characterized extensively, although the site of nuclear substrate turnover has not been established definitively. We report here that two well-characterized nuclear proteins are stabilized in nuclear export mutants in Saccharomyces cerevisiae. The requirement for nuclear export defines a new regulatory step in intracellular proteolysis. |
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| Keywords: | export degradation proteasome substrate ubiquitin |
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