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Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil |
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| Authors: | Aline Garcia Kozlowski Megmar Aparecida dos Santos Carneiro Márcia Alves Dias de Matos Sheila Araújo Teles Jo?o Alves Araújo Filho Koko Otsuki Ana Carolina Paulo Vicente Regina Maria Bringel Martins |
| Affiliation: | 1. Instituto de Patologia Tropical e Saúde Pública ;2. Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, GO, Brasil ;3. Hospital de Doenças Tropicais Anuar Auad, Goiânia, GO, Brasil ;4. Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil |
| Abstract: | Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis(TB). Both infections are highly endemic in Brazil. The aim of this study was toassess the prevalence of HTLV-1/2 in TB patients in Central-West Brazil and toperform a genetic characterisation of the respective isolates. Of the 402 patients,six (1.49%) were positive for anti-HTLV and five (1.24%; 95% confidence interval:0.46-3.05) were infected with HTLV-1/2. Genetic characterisation demonstrated thatthe four HTLV-1 isolates belonged to the Transcontinental subgroup A of theCosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c).The prevalence of HTLV infection observed in this study is higher than that observedin local blood donors and the HTLV-1 and 2 subtypes identified are consistent withthose circulating in Brazil. |
| Keywords: | HTLV-1 HTLV-2 tuberculosis prevalence |