| 温度对胸腺激素理化性质和生物活性的影响 |
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| 引用本文： | 陈紫榕,于华生.温度对胸腺激素理化性质和生物活性的影响[J].微生物学免疫学进展,1996,24(2):49-52. |
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| 作者姓名： | 陈紫榕 于华生 |
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| 作者单位： | 空军福州医院临床免疫研究室，福州金山制药厂，福州大学化学系 |
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| 摘 要： | 为探讨胸腺激素耐受的最高温度，将胸腺因子Ｄ、胸腺素和胸腺肽加热至１２１℃、１２５℃、１３０℃，直至１９０℃１５ｍｉｎ。结果：加热１４０℃以下１５ｍｉｎ，其色泽、澄明度、紫外吸收峰、旋光度、ＰＨ值、蛋白质含量、相对比移值和活性玫瑰花形成率，与未加热样品比较，均无明显变化；加热至１５０℃以上，上述指标除紫外吸收峰外，余均显著改变。结果表明，胸腺因子Ｄ、胸腺素和胸腺肽能耐受１４０℃１５ｍｉｎ。
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| 关 键 词： | 胸腺激素，耐热，活性，理化性质 |
A Study of the Heat on Physicochemical Properties and Bioactivities of Thymus Hormone |
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| Chen,Zirong et,al.A Study of the Heat on Physicochemical Properties and Bioactivities of Thymus Hormone[J].Progress In Microbiology and Immunology,1996,24(2):49-52. |
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| Authors: | Chen Zirong et al |
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| Abstract: | The influence of heat on physicochemical properties and bioactivities of thymus hormone was observed when the thymus factor D (TFD),thymosin (TM) and thymopeptide (TP) were heated to 121,125,130,140,150,160,170,180,190 degrees centigrade for 15 min. When the temperature under 140 degrees centigrade, the color, clarity, ultraviolet absorb peak,optical rotation,PH valueprotien content,Rf value and active rosette forming rate were not significantly change compared with those of TH before heat.But when the temperature over 150 degrees centigrade,these markers as mentioned above,except ultraviolet absorb peak were all significantly changed.These results suggest that the TFD,TM,and TP resisted 140 degrees centigrade 15 miniutes. |
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| Keywords: | Thymus hormone Thermostability Activity Physicochemical properties |
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