NK1 antagonists based on seven membered lactam scaffolds |
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| Authors: | Elliott Jason M Carlson Emma J Chicchi Gary G Dirat Olivier Dominguez Maria Gerhard Ute Jelley Richard Jones A Brian Kurtz Marc M Tsao Kwei lan Wheeldon Alan |
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| Affiliation: | Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. jason@elliottj25.fsnet.co.uk |
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| Abstract: | ![]()
A new class of high affinity hNK1R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. |
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