| 一个未知的特异结合雌激素效应元件编码链的单链结合蛋白 |
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| 引用本文： | 朱国璋,刘峻,张友端,张永莲. 一个未知的特异结合雌激素效应元件编码链的单链结合蛋白[J]. Acta biochimica et biophysica Sinica, 1996, 0(4) |
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| 作者姓名： | 朱国璋 刘峻 张友端 张永莲 |
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| 作者单位： | 中国科学院上海生物化学研究所分子生物学国家重点实验室 |
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| 摘 要： | 本文介绍一个不是雌激素受体（ＥＲ）却能专一地结合雌激素效应元件（ＥＲＥ）编码单链的单链结合蛋白，对此蛋白在细胞中的定位、组织中的分布、热稳定性、同二价金属离子的关系作一初步研究。发现其受雌激素负调控。此蛋白在人病理样品２９例乳癌中同ＥＲ的含量似有一定的负相关关系，讨论了上述结果的意义。
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| 关 键 词： | 雌激素效应元件，雌激素受体，单链结合蛋白 |
An Unknown Protein Binding Specifically To the Coding Strand of the Estrogen Responsive Element |
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| ZHU Guo-Zhang,LIU Jun,ZHANG You-Duan and ZHANG Yong-Lian. An Unknown Protein Binding Specifically To the Coding Strand of the Estrogen Responsive Element[J]. Acta biochimica et biophysica Sinica, 1996, 0(4) |
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| Authors: | ZHU Guo-Zhang LIU Jun ZHANG You-Duan ZHANG Yong-Lian |
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| Abstract: | An unknown protein,designated ERE-C-SSBP,which binds to the single coding strand of estrogen response element(ERE)tightly and specifically,has been discovered unexpectedly during an attempt to establish an ER-ERE gel retardation assay with a 13bp core fragment of the ERE as a probe.Some of its characteristics,such as subcellular location,tissue distribution,heat stability,relation with divalent metal ions,are reported. Interestingly,it may be down-regulated by estrogen.Its value in 29 breast carcinoma samples is to some degree in reverse correlationship with that of ER. The significance of these findings is discussed. |
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| Keywords: | Estrogen responsive element Estrogen receptor Single-strand binding protein |
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