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Glyceollin, a soybean phytoalexin with medicinal properties |
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| Authors: | Ng Tzi Bun Ye Xiu Juan Wong Jack Ho Fang Evandro Fei Chan Yau Sang Pan Wenliang Ye Xiu Yun Sze Stephen Cho Wing Zhang Kalin Yanbo Liu Fang Wang He Xiang |
| Affiliation: | 1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories Hong Kong, China 2. College of Biological Science and Technology, FuZhou University, Fuzhou, China, 350002 3. School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China 4. Department of Microbiology, Nankai University, Tianjin, China 5. State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing, 100094, China |
| Abstract: | This review covers the biosynthesis of glyceollin and its biological activities including antiproliferative/antitumor action (toward B16 melanoma cells, LNCaP prostate cancer cells, and BG-1 ovarian cancer cells), anti-estrogenic action (through estrogen receptors ??- and ??-), antibacterial action (toward Erwinia carotovora, Escherichia coli, Bradyrhizobium japonicum, Sinorhizobium fredii ), antinematode activity, and antifungal activity (toward Fusarium solani, Phakospora pachyrhizi, Diaporthe phaseolorum, Macrophomina phaseolina, Sclerotina sclerotiorum, Phytophthora sojae, Cercospora sojina, Phialophora gregata, and Rhizoctonia solani). Other activities include insulinotropic action and attenuation of vascular contractions in rat aorta. |
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