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AI-2 does not function as a quorum sensing molecule inCampylobacter jejuniduring exponential growthin vitro |
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| Authors: | Kathryn Holmes Tim J Tavender Klaus Winzer Jerry M Wells and Kim R Hardie |
| Institution: | (1) Pathogens: Molecular Microbiology, BBSRC Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK;(2) School of Molecular Medical Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Clifton Boulevard, University Park, Nottingham, NG7 2RD, UK;(3) Department of Clinical Medicine, Trinity College, Adelaide and Meath Hospital, Dublin 24, Ireland;(4) Michael Smith Building, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK;(5) Host-Microbe Interactomics, Animal Sciences Department, University of Wageningen, The Netherlands |
| Abstract: | BackgroundCampylobacter jejunicontains a homologue of theluxSgene shown to be responsible for the production of the signalling molecule autoinducer-2 (AI-2) inVibrio harveyiandVibrio cholerae. The aim of this study was to determine whether AI-2 acted as a diffusible quorum sensing signal controllingC. jejunigene expression when it is produced at high levels during mid exponential growth phase. |
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