Alterations in plasma-membrane functions after poliovirus infection |
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Authors: | Andras Schaefer Reinhard Zibirre Peter Kabus Jutta Kühne Gebhard Koch |
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Affiliation: | (1) Abteilung Molekularbiologie, Universität Hamburg, Grindelallee 117, D-2000 Hamburg 13, Federal Republic of Germany |
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Abstract: | After exposure of HeLa cells to poliovirus there is a rapid decline (within minutes) in fluorescence polarization of DPH (1,6-diphenyl-1,3,5-hexatriene). Within one hour after infection the (Na+/K+)ATPase activity of an isolated plasma-membrane-rich fraction is enhanced, the cell volume decreases, and the intracellular concentration of a potent low-molecular-weight inhibitor of host protein synthesis increases. |
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