Effect of seaweed preparations on murine immunocytes |
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Authors: | Sadanori Mizukoshi Hiroyoshi Matsuoka Kyoko Nakamura Fuminori Kato |
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Institution: | (1) Biochemistry Research Laboratory, Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Kusatsu, Shiga 525, Japan |
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Abstract: | During a screening programme for new medical agents, many aqueous extracts from 59 species of seaweed were found to possess bioactivity against murine immunocytes. Thirty-eight extracts (8 green, 12 brown, 18 red algae) showed suppressive effects on the mitogenic response. Furthermore, 16 extracts (2 green, 6 brown, 8 red algae) suppressed the production of Interleukin 1 (1L-1) from murine macrophage. Using the murine mixed lymphocyte reaction assay, suppressive effects were observed in 4 red algae, but none in green or brown algae. Nine seaweed extracts suppressed the production of secondary antibody (IgG, IgM). Extracts of 3 red algae suppressed strongly the proliferation of bone marrow cells, but 2 other red algae caused stimulation above 200%. This is apparently the first report showing immunosuppressive activity from marine algae. |
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Keywords: | marine algae immunosuppressive activity murine immunocyte mitogenic response Interleukin 1 mixed lymphocyte reaction |
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