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Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum |
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| Authors: | Boxell Annika Lee Stephanie Hui Chin Jefferies Ryan Watt Paul Hopkins Richard Reid Simon Armson Anthony Ryan Una |
| Affiliation: | a Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia b Drug Discovery Technology Group, Telethon Institute for Child Health Research, Subiaco, School of Paediatrics and Child Health, University of Western Australia, Australia c Phylogica Ltd., Perth, WA, Australia d Division of Health Sciences, School of Nursing, Murdoch University, Murdoch, WA 6150, Australia |
| Abstract: | This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen. |
| Keywords: | Cryptosporidium Pyrrhocoricin Delivery vehicle Peptides |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |