Formation of extracellular neutral proteinase and the stringent response inBacillus subtilis |
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| Authors: | K. Riedel A. Schroeter P. Liebs J. P. Graba M. Hecker D. Schrapel |
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| Affiliation: | (1) Central Institute of Molecular Biology, 1115 Berlin-Buch, GDR;(2) Ernst-Moritz-Arndt University, 2200 Greifswald, GDR |
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| Abstract: | The kinetics of extracellular neutral proteinase synthesis by an isogenic stringent (IS58) and a relaxed (IS56) strain ofB. subtilis were compared. The specific enzyme formation rate by the stringent strain was higher than that of the relaxed one. Norvaline addition (1 mg/mL) induced the formation of pppGpp and ppGpp, respectively, as well as the appearance of extracellular neutral proteinase activities in cultures of the stringent strain IS58 and a strain with high proteinase production (ZF-178) only. These correlations support the suggestion that (p)ppGpp are involved in the regulation processes responsible for production of extracellular neutral proteinases byB. subtilis. Dedicated to Prof. Dr. F. Mach on the occasion of his 60th birthday. |
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