外周血晚期糖基化终产物、外周血锌转运蛋白8与糖尿病脂代谢紊乱的相关性

摘要 目的：探讨外周血晚期糖基化终产物(the Receptor of Advanced Glycation Endproducts，RAGE)、外周血锌转运蛋白8(Zinc transporter 8，ZnT8)与糖尿病脂代谢紊乱的相关性。方法：2015年8月到2020年9月选择在本院诊治的2型糖尿病患者118例作为糖尿病组，同期选择在本院体检的健康人118例作为对照组。检测两组外周血RAGE、ZnT8、脂代谢水平，调查患者的一般资料并进行相关性分析。结果：糖尿病组的血清RAGE、ZnT8含量都高于对照组(P<0.05)。糖尿病组的甘油三酯(Triglycerides，TG)、总胆固醇(Total cholesterol，TC)、低密度脂蛋白(Low-density lipoprotein cholesterol，LDL-C)、视黄醇结合蛋白4(Retinol binding protein 4，RBP4)、游离脂肪酸(Free fatty acid，FFA)含量高于对照组(P<0.05)，高密度脂蛋白(High density liptein cholesterol，HDL-C)、脂联素(Adiponectin，APN)含量低于对照组(P<0.05)。在糖尿病组中，Pearson分析显示RAGE、ZnT8与TG、TC、LDL-C、APN、HDL-C、FFA、RBP4都存在相关性(P<0.05)。多因素logistic回归分析显示RAGE、ZnT8、TG、TC、LDL-C、APN、HDL-C、FFA、RBP4都为影响患者空腹血糖的重要因素(P<0.05)。结论：糖尿病患者的外周血RAGE、ZnT8多呈高表达状况，也多伴随有脂代谢紊乱，RAGE、ZnT8与脂代谢指标存在相关性，也可共同参与调节糖尿病的发生与发展。

Correlation between Advanced Glycation end Products in Peripheral Blood, Zinc Transporter 8 in Peripheral Blood and Lipid Metabolism Disorders in Diabetes

ABSTRACT Objective: To investigate the relationship between the Receptor of Advanced Glycation Endproducts (RAGE), Zinc transporter 8 (ZnT8) and lipid metabolism disorders in diabetes. Methods: From August 2015 to September 2020, 118 cases of patients with type 2 diabetes who were diagnosed and treated in this hospital were selected as the diabetes group, and 118 cases of healthy people who given physical examination in this hospital were selected as the control group during the same period. The levels of RAGE, ZnT8 and lipid metabolism in the peripheral blood of the two groups were detected, the general data of the patients were investigated and the correlation analysis were carried out. Results: The serum levels of RAGE and ZnT8 in the diabetes group were higher than those in the control group (P<0.05). The levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), Free fatty acid (FFA). Retinol binding protein 4 (RBP4) in the diabetic group were higher than the control group (P<0.05), the levels of high density lipoprotein (HDL-C) and adiponectin (APN) were lower than the control group (P<0.05). In the diabetes group, Pearson analysis showed that RAGE and ZnT8 were correlated with TG, TC, LDL-C, APN, HDL-C, FFA, RBP4 (P<0.05). Multivariate logistic regression analysis showed that RAGE, ZnT8, TG, TC, LDL-C, APN, HDL-C, FFA, RBP4 were all important factors affected fasting blood glucose (P<0.05). Conclusion: Peripheral blood RAGE and ZnT8 of diabetic patients are mostly highly expressed, and most of them are accompanied by lipid metabolism disorders. RAGE and ZnT8 are related to lipid metabolism indicators and can also participate in the regulation of the occurrence and development of diabetes.