P物质在子宫内膜异位症中的表达及其意义

目的:探讨P物质(substance P,SP)在子宫内膜异位症(endometriosis,EM)中的表达及其意义。方法:采用免疫组织化学法检测2012年10月至2013年4月在哈尔滨医科大学附属第一医院经腹腔镜及病理证实的EM患者异位子宫内膜组织20例,与其配对的在位子宫内膜组织10例以及因非EM(子宫肌瘤)行腹腔镜下子宫全切术或肌瘤核除患者的正常子宫内膜组织20例中SP的表达情况,并分析和比较术中盆腔粘连发生情况。结果:SP在EM患者的异位子宫内膜、在位子宫内膜及非EM患者的正常子宫内膜的阳性表达率分别为75%、80%、20%,异位子宫内膜和在位子宫内膜比较无显著性差别(P=1.0),但均高于非EM患者的正常子宫内膜,差异均有统计学意义(P=0.002,P=0.004);EM组盆腔粘连的阳性率高于非EM组,EM患者异位子宫内膜中SP阳性组盆腔粘连阳性率高于SP阴性组,差异均有统计学意义(P=0.001,P=0.032),非EM患者正常子宫内膜中SP阳性组盆腔粘连阳性率与SP阴性组相比,差异不具有统计学意义(P=0.061)。结论:SP在EM的异位子宫内膜和在位子宫内膜中的表达上调,并与EM合并盆腔粘连有关,其具体机制尚有待进一步的研究。

Expression of Substance P and its Significance in the Endometriosis

Objective:To explore the expression and significance of Substance P (SP) in the endometriosis.Methods:The expression of SP in 20 cases of ectopic endometria from patients with EM, 10 cases of eutopic endometria from the same patients with EM and 20 cases of normal endometria from patients with hysteromyoma suffering laparoscopic hysterectomy or myomectomy were determined by immunohistochemical method and these endometria were confirmed by laparoscopy and pathology in the First Affiliated Hospital of Harbin Medical University from October 2012 to April 2013 and the incidence of cases with pelvic adhesions in the surgery was analyzed and compared.Results:The positive percentage of ectopic, eutopic and normal endometria were 75 %, 80 % and 20 %, respectively. There was no difference between ectopic and eutopic endometria (P=1.0); Both positive percentages of ectopic and eutopic endometria were significantly higher than that of the normal endometria (P=0.002, P=0.004); For the pelvic adhesion , the positive percentage of EM was higher than that of the control group and the SP-positive group was higher than the SP-negative group in the ectopic endometria, both of the differences were significant (P=0.001, P=0.032) , but there was no significant difference between SP-positive group and the SP-negative group in the normal endometria (P=0.061).Conclusion:SP in the ectopic and eutopic endometria of EMis up-regulated and it is related with patients of EMwith pelvic adhesion, but the exacted mechanismneeds further study.