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Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility
Authors:Jennifer W. Hill  Carol F. Elias  Makoto Fukuda  Kevin W. Williams  Eric D. Berglund  William L. Holland  You-Ree Cho  Jen-Chieh Chuang  Yong Xu  Michelle Choi  Danielle Lauzon  Charlotte E. Lee  Roberto Coppari  James A. Richardson  Jeffrey M. Zigman  Streamson Chua  Philipp E. Scherer  Bradford B. Lowell  Jens C. Brüning  Joel K. Elmquist
Affiliation:1. Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, College of Medicine, The University of Toledo, Toledo, OH 43614, USA;2. Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;3. Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;4. Department of Pharmacology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;5. Department of Pathology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA;6. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA;7. Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;8. Institute for Genetics, Center for Molecular Medicine Cologne (CMMC) and Cologne Excellence Cluster for Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47, D-50674 Cologne, Germany
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