| 下丘脑减压区微量注射牛磺酸对血压的影响 |
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| 引用本文： | Chen L,Li RJ,Zhou YB,Chen JJ. 下丘脑减压区微量注射牛磺酸对血压的影响[J]. 生理学报, 1999, 51(5): 593-596 |
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| 作者姓名： | Chen L Li RJ Zhou YB Chen JJ |
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| 作者单位： | 青岛大学医学院生理学教研室!青岛,266021,青岛疗养院检验科!青岛,266000,青岛大学医学院生理学教研室!青岛,266021,青岛大学医学院生理学教研室!青岛,266021 |
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| 摘 要： | 实验采用微量注射和荧光分光光度测定的方法,探讨了下丘脑前部减压区牛磺酸对大鼠血压的影响及其可能的机制。结果显示：（１）下丘脑前部减压区微量注射牛磺酸可致大鼠血压降低;（２）侧脑室注射β受体阻断剂心得安可阻断牛磺酸的降压效应。而α受体阻断剂酚妥拉明对牛磺酸的降压效应无明显影响;（３）下丘脑前部减压区注射牛磺酸后,可使下丘脑去甲肾上腺素含量明显增高。
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| 关 键 词： | 牛磺酸 下丘脑前部 减压区 血压 |
Effect of microinjection of taurine into anterior hypothalamic area on blood pressure in rats |
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| Chen L,Li R J,Zhou Y B,Chen J J. Effect of microinjection of taurine into anterior hypothalamic area on blood pressure in rats[J]. Acta Physiologica Sinica, 1999, 51(5): 593-596 |
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| Authors: | Chen L Li R J Zhou Y B Chen J J |
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| Affiliation: | Department of Physiology, Faculty of Medicine, Qingdao University, Qingdao 266021. |
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| Abstract: | The effect of taurine in anterior hypothalamic area (AHA) on blood pressure was investigated by means of microinjection and spectrophotofluorometry. The results are as follows. (1) Taurine microinjected into AHA decreased blood pressure markedly. (2) The depressor response of taurine in AHA could be antagonized by propranolol, but not by phentolamine. (3) After microinjection of taurine into AHA, the content of norepinephrine in hypothalamus increased significantly. The above results suggest that taurine in AHA attenuates blood pressure by increasing the content of norepinephrine, probably mediated by beta-adrenergic receptor. |
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| Keywords: | taurine anterior hypothalamic area norepinephrine blood pressure rat |
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