抗菌肽的作用机制、生物活性及应用研究进展

抗菌肽广泛存在于生物界,是辅助生物机体抵抗外来病原体入侵的重要防御分子。抗菌肽不仅能抑制、杀灭多种细菌,而且具有抗真菌、抗寄生虫、抗病毒、抗肿瘤和免疫调节等生物学活性。抗菌肽的作用机制与传统抗生素不同,不仅具有广谱抗微生物作用,而且不易诱导机体产生耐药性,因此,在治疗临床耐药菌株方面具有极大的开发潜力。

Advances on mechanism,bioactivity and application of antimicrobial peptides

Antimicrobial peptides are produced by almost all species of lives as an important molecule against pathogenetic microorganisms in host's immune defense system.Antimicrobial peptides have biological activities on immunoregulation and the mechanism for unique effect of them contributes to a broad spectrum of resistance for bacteria,fungi,parasites,viruses and tumors with a low tendency of drug resistance,which has a great potential to develop a new type of peptide antibiotics against the increasing multi-drug resistant clinical infections.In this paper,the classification,structure-function relationship,effect mechanism and prospects for application are reviewed.