Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus) |
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| Authors: | K Bender R T Seibert T F Wienker V Kren M Pravenec S Bissbort |
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| Institution: | (1) Institut für Humangenetik und Anthropologie der Universität Freiburg, Breisacher Str. 33, D-79106 Freiburg, Germany;(2) Biologicky Ustav, University Karlovy, Albertov 4, 12800 Praha,  eska Republika;(3) Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, KR, eska Republika |
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| Abstract: | A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designatedMgd1, is expressed in liver and kidney. Inbred rat strains have fixed either alleleMgd1
a
or alleleMgd1
b
. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence thatMgd1 is linked toPep3 andFh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases:Mgd2, present in liver and kidney, andMgd3, present only in heart.Supported by the Deutsche Forschungsgemeinschaft (Grant Be 352/18-1). |
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| Keywords: | methylglyoxal methylglyoxal dehydrogenase loci 1 2 3 Mgd1 polymorphism heart-specificMgd3 expression glyoxalase I rat chromosome 13 |
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