Parallel synthesis and antileishmanial activity of ether-linked phospholipids |
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| Authors: | Coghi Paolo Vaiana Nadia Pezzano Maria G Rizzi Luca Kaiser Marcel Brun Reto Romeo Sergio |
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| Affiliation: | Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Università degli Studi di Milano, Via G. Mangiagalli 25, 20133 Milano, Italy. |
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| Abstract: | ![]()
The synthesis and antileishmanial activity of 18 edelfosine analogues are described. Compounds were obtained in parallel combining solid phase and solution phase synthesis. The most active analogue is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution determines the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized. |
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