| CYP2J2*7SNP与心血管疾病相关性的研究现状 |
| |
| 引用本文： | 詹同运,石磊,赵树进.CYP2J2*7SNP与心血管疾病相关性的研究现状[J].生物学杂志,2011,28(4):81-83. |
| |
| 作者姓名： | 詹同运 石磊 赵树进 |
| |
| 作者单位： | 广州军区总医院药剂科,广州,510010 |
| |
| 摘 要： | 花生四烯酸的CYP450环氧化物酶(主要是CYP2C和2J亚家族)代谢物EETs具有心血管保护作用,包括血管扩张、抗炎、抗血栓、抗细胞凋亡、促进缺血组织平滑肌细胞生长及血管生成等作用。而基因多态性会导致酶活性的下降或酶合成量的减少,使得相应代谢物合成量减少,并可能与疾病的发生息息相关。因此科研工作者从基因出发,寻找疾病的易感基因,以期从分子水平治疗疾病。CYP450环氧化物酶基因突变的位点很多,仅就其花生四烯酸代谢产物之一EETs在心血管中的作用和CYP2 J2中一个普遍存在且具有功能意义的突变点G-50T(即CYP2 J2*7)单核苷酸多态性与心血管疾病关系的研究现状作一综述。
|
| 关 键 词： | 细胞色素P450 基因多态性 心血管疾病 CYP2J2 |
Overview on the relationship between CYP2J2*7 SNP and cardiovascular disease |
| |
| ZHAN Yun-tong,SHI Lei,ZHAO Shu-jin.Overview on the relationship between CYP2J2*7 SNP and cardiovascular disease[J].Journal of Biology,2011,28(4):81-83. |
| |
| Authors: | ZHAN Yun-tong SHI Lei ZHAO Shu-jin |
| |
| Institution: | ZHAN Yun-tong,SHI Lei,ZHAO Shu-jin(Pharmacy of Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China) |
| |
| Abstract: | CYP450 epoxide enzyme(mainly CYP2C and CYP2J subfamily) can metabolize arachidonic acid into EETs which have many cardiovascular protective effect,including expansion vessels,anti-inflammatory,anti-thrombotic,anti-apoptosis,the promotion of ischemic tissue growth and angiogenesis of smooth muscle cells.Gene polymorphism reduces enzyme's amount and makes the corresponding reduction in metabolism synthesis,and may be closely related to some disease.Therefore researchers can look for disease susceptibility gen... |
| |
| Keywords: | CYP2J2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
