SYNTHESIS OF 8-AMINO AND 8-SUBSTITUTED AMINO DERIVATIVES OF ACYCLIC PURINE NUCLEOSIDE AND NUCLEOTIDE ANALOGS. ALKYLATION OF 8-SUBSTITUTED PURINE BASES

Two synthetic approaches were used for preparation of 8-amino-, 8-methyl- amino-, and 8-dimethylaminoadenine and -guanine analogs of PME and HPMP series: (a) direct modification of 8-bromopurine acyclic nucleotide analogs at the 8-position of the base, (b) alkylation of 8-modified purine bases with alkylation agents.