有氧跑台干预对高龄小鼠心血管疾病危险因子影响研究

探讨有氧运动训练是否会增进高龄小鼠的运动生理功能并降低心血管疾病的危险因子。以80周龄大的C57BL/6J与CBA混种品系小鼠12只为实验对象,进行各项生理数值检测后,于小鼠22月龄时,以随机的方式分成运动组(每周5 d;每天50 min跑步机训练;共8周)与对照组,观察小鼠在训练后的各项生理数值变化,包含基础代谢率、最大摄氧量、血压及血液生化值等数据。本研究以SPSS 18.0统计软件为工具,以成对样本T检验分析进行统计分析。与前测比较,运动组小鼠在最大摄氧量、基础代谢率与高密度脂蛋白维持不变,但对照组皆显著下降;运动组血液中甘油三脂降低,但对照组则维持不变;运动组血压维持不变,但对照组却显著上升。8周有氧运动训练可推迟小鼠因老化所引起的基础代谢率与有氧能力衰退,并可通过稳定血压与降低血脂减少罹患心血管疾病的危险因子。

Aerobic Treadmill Intervention on Cardiovascular Disease in Elderly Mice Risk Factor Impact Study

To investigate whether aerobic exercise training can improve the exercise physiological function of elderly mice and reduce the risk factors of cardiovascular disease.Twelve mice of 80-week old C57BL/6J and CBA mixed strains were tested for physiological values.At 22 months of age,mice were randomly divided into exercise groups(5 days per week).50 minutes of treadmill training per day for 8 weeks;And the control group were observed for changes in physiological values of the mice after training,including basal metabolic rate,maximum oxygen uptake,blood pressure,and blood biochemical values.In this study,SPSS 18.0 statistical software was used as a tool to perform statistical analysis by paired sample T test analysis.Compared with the previous test,the maximal oxygen uptake,basal metabolic rate,and high-density lipoprotein remained unchanged in the exercise group,but the control group all significantly decreased;The triglyceride levels in the exercise group decreased,but the control group Remained unchanged;blood pressure in the exercise group remained unchanged,but the control group increased significantly.Eight-week aerobic exercise training can postpone basal metabolic rate and aerobic capacity decline induced by aging in mice,and can also be a risk factor for cardiovascular disease by stabilizing blood pressure and reducing blood lipids.