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| 滇产植物乌墨中胰岛素增敏活性成分 | |
| 引用本文： | 李石飞,黄年旭,郝小江,李玲,李顺林. 滇产植物乌墨中胰岛素增敏活性成分[J]. 云南植物研究, 2009, 31(5): 469-473. DOI: 10.3724/SP.J.1143.2009.09111 |
| 作者姓名： | 李石飞 黄年旭 郝小江 李玲 李顺林 |
| 作者单位： | 1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204;中国科学院研究生院,北京,100049 2. 昆明医学院云南省天然药物药理重点实验室,云南,昆明,650031 3. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204 |
| 基金项目： | 国家自然科学基金，云南省自然科学基金 |
| 摘 要： | 从乌墨（Syzygium cumini）根的甲醇提取物中分离鉴定8个已知化合物，并对其进行了经高糖、高胰岛素处理后胰岛素抵抗L6肌管细胞糖摄取活性的筛选。初步研究结果表明，其中7个化合物在有无胰岛素刺激下均能明显促进葡萄糖的利用。在无胰岛素刺激状态下，浓度为10μgml^-1时，无羁萜（1）的葡萄糖消耗量比抵抗细胞增加了17．35％；在有胰岛素刺激状态下，浓度为0．1μgml^-1，5，7，3’，4’，5＇-五羟基黄酮（8）葡萄糖消耗量比抵抗细胞增加了51．11％。 |
| 关 键 词： | 乌墨 化学成分 胰岛素抵抗 糖摄取 |
Effect of Chemical Constituents from Syzygium cumini (Myrtaceae)on Glucose Uptake in Insulin-resistant L6 Cells* |
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| LI Shi-Fei,HUANG Nian-Xu,HAO Xiao-Jiang,LI Ling,LI Shun-Lin. Effect of Chemical Constituents from Syzygium cumini (Myrtaceae)on Glucose Uptake in Insulin-resistant L6 Cells*[J]. Acta Botanica Yunnanica, 2009, 31(5): 469-473. DOI: 10.3724/SP.J.1143.2009.09111 | |
| Authors: | LI Shi-Fei HUANG Nian-Xu HAO Xiao-Jiang LI Ling LI Shun-Lin |
| Affiliation: | LI Shi-Fei, HUANG Nian-Xu, HAO Xiao-Jiang, LI Ling, LI Shun-Lin(1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; 2 Graduate University of Chincse Academy of Sciences, Beijing 100049, China; 3 Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China) |
| Abstract: | Eight known compounds isolated from the roots of Syzygium cumini were evaluated for their ability to enhance the glucose consumption in insulin-resistant L6 muscle cells induced by high concentration-insulin and glucose. All of compounds significantly enhanced the glucose consumption of insulin-resistant cells in the presence and absence of insulin. The glucose consumption was increased 17.35% and 51.11% by compound 1 (friedelin) at a concentration of 10 μg ml~(-1) without insulin and by compound 8 (5, 7, 3', 4', 5'-pentahydroxyflavone) at a concentration of 0.1 μg ml~(-1) with insulin, respectively. |
| Keywords: | Syzygium cumini Chemical constituents Insulin resistance Glucose uptake |
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