Synthesis of 2'-([1,2,3]triazol-1-yl)-2'-deoxyadenosines |
| |
Authors: | O'Mahony Gavin Svensson Sara Sundgren Andreas Grøtli Morten |
| |
Institution: | Department of Chemistry, Medicinal Chemistry, G?teborg University, G?teborg, Sweden. |
| |
Abstract: | A reliable and efficient protocol for the synthesis of 2 '-(1,2,3]triazol-1-yl)-2 '-deoxyadenosine derivatives from vidarabine is presented. Vidarabine was converted to 2'-azido-2'-deoxy-3',5-O-(tetraisopropyldisiloxane-1,3-diyl)-adenosine. This azide was used as the starting material for the Cu(I)-catalyzed parallel synthesis of 1,2,3-triazoles using a variety of alkynes. The reactions proceeded in good yield and gave almost exclusively the 1,4-disubstituted 1,2,3-triazoles. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|