Cooperativity of adaptive and innate immunity: implications for cancer therapy |
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Authors: | Anil Shanker Francesco M Marincola |
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Institution: | (1) Laboratory of Lymphocyte Function, Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA;(2) Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA;(3) Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and the Trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD 20892, USA |
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Abstract: | The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic
two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer,
indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity
in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated
inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk
could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases
that normally defy immune control. |
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