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Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature |
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| Authors: | Luize Otero Daiane Correa de Souza Rita de Cássia Tavares Bernadete Evangelho Gomes Telma Fran?a Padilha Luiz Fernando Bouzas Teresa de Souza Fernandez Eliana Abdelhay |
| Institution: | Centro de Transplante de Medula Óssea, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. |
| Abstract: | Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient’s bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells. |
| Keywords: | monosomy 7 donor cell leukemia bone marrow transplantation severe aplastic anemia |