Allelic variants of DYX1C1 are not associated with dyslexia in India |
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| Authors: | Pushpa Saviour Satish Kumar U Kiran Rajasekhara Reddy Ravuri V R Rao and Nallur Basappa Ramachandra |
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| Institution: | Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore-570 006, India;1Anthropological Survey of India, Southern Regional Centre, Manav Bhavan, Bogadi II Stage, Mysore-570 006, India |
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| Abstract: | Dyslexia is a hereditary neurological disorder that manifests as an unexpected difficulty in learning to read despite adequate intelligence, education, and normal senses. The prevalence of dyslexia ranges from 3 to 15% of the school aged children. Many genetic studies indicated that loci on 6p21.3, 15q15-21, and 18p11.2 have been identified as promising candidate gene regions for dyslexia. Recently, it has been suggested that allelic variants of gene, DYX1C1 influence dyslexia. In the present study, exon 2 and 10 of DYX1C1 has been analyzed to verify whether these single nucleotide polymorphisms (SNPs) influence dyslexia, in our population. Our study identified 4 SNPs however, none of these SNPS were found to be significantly associated with dyslexia suggesting DYX1C1 allelic variants are not associated with dyslexia. |
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| Keywords: | Candidate gene chromosome dyslexia DYX1C1 |
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