Conformationally restricted dinucleotides: tandem ring-closing metathesis and hydrogenation approach |
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| Authors: | Børsting Philip Nielsen Poul |
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| Affiliation: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. |
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| Abstract: | Cyclic dinucleotides with saturated connections between a nucleobase and the phosphate are synthesised using a tandem ring-closing metathesis (RCM) and hydrogenation protocol and found to be significantly stabilised towards ammonia. |
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