Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions |
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Authors: | Albaek Nanna Ravn Jacob Freitag Morten Thomasen Helena Christensen Nanna K Petersen Michael Nielsen Poul |
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Affiliation: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. |
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Abstract: | Ring-closing metathesis (RCM) is applied as a new and powerful technology in the construction of nucleoside analogues that are conformationally restricted in S-type conformations due to additional 3',4'- and/or 3',5'-linkages. |
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