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The use of triisopropylsilyl-oxymethyl (TOM) in the synthesis of anti-telomerase 2-5A antisense compound RBI 011 |
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| Authors: | Cramer Hagen Rhea Rachele Okicki Jim Yirava Karen Silverman Robert |
| Affiliation: | Ridgeway Biosystems Inc., Cleveland, Ohio, USA. |
| Abstract: | The 2-5A antisense compound RBI 011 targeting telomerase RNA was synthesized using the triisopropylsilyl-oxymethyl (TOM) group for the 3'-hydroxyl protection of 2',5'-linked RNA. |
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