Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a |
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| Authors: | Takahiro Shiga Yoshifumi Kimira Hiroshi Mano Tetsunori Kawata Tadahiro Tadokoro Tsukasa Suzuki |
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| Institution: | 1. Faculty of Applied Bioscience, Department of Applied Biology and Chemistry, Tokyo University of Agriculture, Tokyo, Japan;2. Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition, Josai University, Saitama, Japan;3. Division of Life, Health, and Sports Education, Graduate School of Education, Okayama University, Okayama, Japan |
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| Abstract: | Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis. |
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| Keywords: | bone disorder inorganic phosphorus Napi2a |
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