Pr-SNTX,a short-chain three-finger toxin from Papuan pigmy mulga snake,is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε) |
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| Authors: | Yoko Yamauchi Hikari Kimoto Xianyu Yang Sergey Filkin Yuri Utkin Tai Kubo |
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| Institution: | 1. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba, Japan;2. College of Animal Science and Biotechnology, Zhejiang A &3. F University , Lin’An, China;4. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences , Moscow, Russian Federation;5. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba, Japan;6. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University , Gifu, Japan |
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| Abstract: | Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr-SNTX, from Pseudechis rossignolii. The amino acid sequence of Pr-SNTX is nearly identical to that of its ortholog in Pseudechis australis. Pr-SNTX protein inhibited muscle-type (α2βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity. |
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| Keywords: | Papuan pigmy mulga snake venom gland three-finger toxin nAChR |
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