Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor |
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| Authors: | Frampton Arthur R Goins William F Cohen Justus B von Einem Jens Osterrieder Nikolaus O'Callaghan Dennis J Glorioso Joseph C |
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| Institution: | Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA. |
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| Abstract: | The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans. |
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