Glucose delays age-dependent proteotoxicity |
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Authors: | Tauffenberger Arnaud Vaccaro Alexandra Aulas Anais Vande Velde Christine Parker J Alex |
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Institution: | CRCHUM Centre of Excellence in Neuromics Département de Pathologie et Biologie Cellulaire Département de Médecine, Université de Montréal, Montréal, Québec, Canada. |
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Abstract: | Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence of age-dependent pathologies in humans. We report here that glucose enrichment delays mutant polyglutamine, TDP-43, FUS, and amyloid-β toxicity in Caenorhabditis elegans models of neurodegeneration by reducing protein misfolding. Dysregulated metabolism is common to neurodegeneration and we show that glucose enrichment is broadly protective against proteotoxicity. |
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Keywords: | aging Caenorhabditis elegans metabolism neurodegeneration protein folding proteotoxicity |
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