The application of single beta-human chorionic gonadotropin (β-hCG) level measurement in women undergoing single blastocyst transfer |
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| Institution: | 1. Health Management Center, Huizhou Central People''s Hospital, Huizhou, Guangdong, China;2. Department of Stomatology, Huizhou Central People''s Hospital, Huizhou, Guangdong, China;3. Department of Breast Surgery, Huizhou Central People''s Hospital, Huizhou, Guangdong, China;1. Beijing Detector Dog Program Facility of China Customs, Beijing, China;2. Animal Science and Technology College, Beijing University of Agriculture, Beijing, China;3. RuiLi Detector Dog Program Facility of China Customs, Yunnan, China;4. China-Japan Friendship Hospital, Beijing, China;5. Beijing Customs of PRC, Beijing, China;1. Masters in Biology of Animal Reproduction, Autonomous Metropolitan University, Campus Iztapalapa, México City, Mexico;2. Department of Biology of Reproduction, Autonomous Metropolitan University, Campus Iztapalapa, México City, Mexico;3. Department of Neuroendocrinology of Reproductive Behavior, Veterinary Faculty, National Autonomous University of Mexico, Mexico;4. Department of Health Sciences, Autonomous Metropolitan University, Campus Iztapalapa, México City, Mexico;5. Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran;6. College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi 030801, People’s Republic of China;7. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran;1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Animal Reproduction Institute, College of Animal Science and Technology, Guangxi University, Nanning 530004, China;2. Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;3. Key Laboratory of Animal Breeding and Reproduction, Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;4. Suqian Institute of Agricultural Sciences, Jiangsu Academy of Agricultural Sciences, Suqian 223800, China;5. Reproductive Medical Center, Renmin Hospital of Wuhan University, JieFang Road 238, Wuhan 430060, China;1. Department of Gynecology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China;2. Department of Orthopedics, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China;1. Department of Oncology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China;2. Department of Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China |
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| Abstract: | We previously explored the associations between β-hCG on the 14th day post–embryo transfer (ET) and reproductive outcomes and established a series of cutoff values to predict different outcomes. The aim of this study was to explore the parameters associated with β-hCG levels and establish β-hCG cutoff values in women undergoing single blastocyst transfer. The patients were transferred with either fresh or frozen-thawed blastocysts. Serum β-hCG levels were compared among different groups. Cutoff values of β-hCG were established and applied to divide the patients into different groups, among which the β-hCG groups were compared. Develop day negatively affected β-HCG levels in those who were pregnant or gave live birth (P < 0.001, 0.008). Inner cell mass significantly affected β-hCG levels in women who were pregnant or gave live birth (P = 0.013, 0.044). Trophectoderm significantly affected β-hCG levels in women with most reproductive outcomes, except biochemical pregnancy (BP) (P = 0.184). The cutoff values of β-hCG for predicting positive outcomes were 194.1, 503.0, 1048.0, and 2590.5 mIU/L. BP rates and adverse pregnancy outcome rates were significantly lower in the higher β-hCG groups (P < 0.001). Shorter gestational age and lower birth weight and length (P = 0.005, 0.041, 0.003) were observed in the lowest-concentration β-hCG group. The application of a single β-hCG measurement was sufficient to predict reproductive outcome in women undergoing blastocyst transfer, under the full consideration of blastocyst parameters. However, the association between β-hCG and obstetric outcomes remains to be investigated and fully explained. |
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| Keywords: | 14 days β-hCG Cutoff values Embryo transfer Reproductive outcomes |
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