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Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo |
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| Authors: | Upadhyay Udita Zhuang Gerald Z. Diatchenko Luda Parisien Marc Kang Yuan Sarantopoulos Konstantinos D. Martin Eden R. Smith Shad B. Maixner William Levitt Roy C. |
| Affiliation: | 1.Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA ;2.Department of Anesthesiology, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada ;3.Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA ;4.John T. MacDonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA ;5.John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA ;6.Department of Anesthesiology, Center for Translational Pain Medicine, Duke University School of Medicine, Durham, NC, USA ;7.University of Miami Miller School of Medicine, Rosenstiel Medical Sciences Building - Room 8010A (R-371), Miami, FL, 33136, USA ; |
| Abstract: | Mammalian Genome - Intracellular calcium is critical in orchestrating neuronal excitability and analgesia. Carbonic anhydrase-8 (CA8) regulates intracellular calcium signaling through allosteric... |
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