Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon |
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| Authors: | Daniel W. Nebert and Robert M. Friedman |
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| Affiliation: | 1Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014;2Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014 |
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| Abstract: | In cell cultures previously treated with homologous interferon, the magnitude of antiviral activity and the degree of stimulation of aryl hydrocarbon hydroxylase induction appear to be directly related. In a highly purified mouse interferon preparation, the factor stimulating hydroxylase induction and the factor directing antiviral activity are inactivated by heating to 70 C or by treating with trypsin. Also, both activities demonstrate species specificity. |
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