Synthesis and biological activity of some known and putative duloxetine metabolites |
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| Authors: | Kuo F Gillespie T A Kulanthaivel P Lantz R J Ma T W Nelson D L Threlkeld P G Wheeler W J Yi P Zmijewski M |
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| Affiliation: | Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 USA. kuo_fengjiun@lilly.com |
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| Abstract: | Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine. |
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