Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres |
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Authors: | M A Geeves K W Ranatunga |
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Affiliation: | Department of Biochemistry, Medical School, University of Bristol, U.K. |
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Abstract: | A method developed to study the effect of increased hydrostatic pressure on the isometric tension of a single muscle fibre is described and experiments done at room temperature (18-22 degrees C) on glycerinated rabbit psoas muscle fibres are presented. Increase of pressure (range 1-10 MPa) caused little change in tension transducer response when a muscle fibre was relaxed. However, there was a reversible depression of isometric tension with an increase of pressure when a fibre was maximally calcium-activated or in rigor; the depression was around 15% for active tension and 30% for rigor tension, for an increase of pressure of 10 MPa (ca. 100 atm). |
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