Lipid microdomains and membrane trafficking in mammalian cells |
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Authors: | Paul Verkade K Simons |
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Institution: | European Molecular Biology Laboratory, Cell Biology Programme, Meyerhofstrasse 1, D-69117, Heidelberg, Germany Tel. +49-6221-387334; fax +49-6221-387512, DE
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Abstract: | This overview summarizes the data for how epithelial cells sort and deliver proteins and lipids to the apical and basolateral cell surface domains. The basolateral pathway uses a Rab-SNARE mechanism for docking and fusion, while the apical route employs a different machinery. This latter mechanism is based on lipid microdomains, composed of clusters of sphingolipids and cholesterol, which function as rafts for apical delivery. The sphingolipid-cholesterol raft mechanism seems to be employed generally by mammalian cells to transport raft-associated proteins to their post-Golgi destinations. |
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