含前S蛋白乙肝疫苗免疫人群效果观察 |
| |
引用本文: | 周书全,程夷,郑菊梅,孟秀园,任魁,李玉.含前S蛋白乙肝疫苗免疫人群效果观察[J].微生物学免疫学进展,1998,26(1):23-25. |
| |
作者姓名: | 周书全 程夷 郑菊梅 孟秀园 任魁 李玉 |
| |
作者单位: | 卫生部兰州生物制品研究所 |
| |
摘 要: | 为考核含前S蛋白乙肝血源疫苗的人群免疫效果,对968名HBV标志阴性的少年人群以10μg×3的免疫剂量及0、1、2月免疫程序进行接种。全程免疫后一月采血检测其抗-HBs免疫应答。结果表明抗-HBs阳性率达96.6%。并对另291名抗-HBc及HCV阳性的少年人群以同样的剂量、同样的免疫程序进行免疫接种,免疫后抗-HBs阳性率为94.16%,且有23.98%的人接种后抗-HBc由接种前的阳性转为阴性,全部观察对象无一例检出HBsAg和其它异常指标
|
关 键 词: | 抗-HBs 含前S蛋白乙肝疫苗 效果观察 |
Observation on the Immune Effect of HBV Vaccine lncluding Pre-S Protein |
| |
Abstract: | In order to determine the immune effects of HBV vaccine including pre-S protein,968 adolescents negative for HBV serologic markers have been received three doses of 10ug HBV vaccine derived from human plasma by a schedule of 0,1,2 month A month later,anti-HBs in them were detected.The result showed that the positive rate of anti-HBs was 96.6%. Additionally 291 adolescents positive for anti-HBs or anti-HCV was vaccinated in the same way. The positive rate was 94.16% and 21.98% of the adolescents formerly positive for anti-HBc became negative for it. None of them developed detectable HBsAg or clinical hepatitis. |
| |
Keywords: | HBV vaccine including pre-S protein anti-HBs effect observation |
本文献已被 CNKI 等数据库收录! |
|