Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants |
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| Authors: | Bhandari Kalpana Srivastava Shipra Shankar Girija |
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| Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. bhandarikalpana@rediffmail.com |
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| Abstract: | A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants. |
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