TGF-β超家族在软骨发生、发育和维持中的作用

转化生长因子b(Transforming growth factor b, TGF-b)超家族包括TGF-b和骨形态发生蛋白(Bone morphogenetic protein，BMP)两个亚家族。TGF-b超家族信号通路的配体、配体拮抗分子、受体、信号转导分子均在软骨内成骨过程中发挥各自独特的作用, 参与调控软骨细胞的谱系分化、增殖、成熟、凋亡和矿化。BMP信号能起始间充质细胞向软骨细胞分化并维持软骨细胞的特性, 在软骨发生过程中起主导作用; 在生长板发育的过程中, BMP信号促进软骨细胞的成熟, 促进成骨, 而TGF-b信号抑制软骨细胞的肥大分化, 维持生长板中适量的软骨细胞; TGF-b信号和BMP信号对于关节软骨的维持和修复都是不可或缺的。因此, TGF-b超家族的重要作用贯穿骨骼发育过程的始终。

Roles of TGF-b superfamily in the genesis, development and maintenance of cartilage

The transforming growth factor b (TGF-b) superfamily is composed of TGF-b subfamily and bone morphogenetic protein (BMP) subfamily. The ligands, ligand antagonists, receptors and intracellular transductors that engage in the TGF-b superfamily signaling pathway play their unique roles during endochondral ossification via regulating the lineage differentiation, proliferation, maturation, apoptosis and mineralization of chondrocytes. BMP signaling dominates chondro-genesis through initiating the chondrocytic commitment of mesenchymal cells and maintaining the chondrocytic phenotype. During the development of growth plate, BMP signaling promotes the maturation of chondrocytes to facilitate ossification, whereas TGF-b signaling inhibits the hypertrophic differentiation to preserve adequate chondrocytes within the growth plate. Both TGF-b signaling and BMP signaling are indispensable for the maintenance and repair of articular cartilage. Therefore, it indicates that TGF-b superfamily may function essentially all throughout the development of skeletons.