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Thrombin and IgE antigen induce formation of inositol phosphates by mouse E-mast cells
Authors:D Baranes  F T Liu  E Razin
Affiliation:1. Institute of Biochemistry, Hebrew University Medical School, PO Box 1172, Jerusalem 91010, Israel;2. Department of Immunology, The Medical Biology Institute, La Jolla, CA 92037, USA
Abstract:Stimulation of murine chondroitin sulfate E containing mast cells (E-MC) in vitro either by thrombin or immunologically resulted in a rapid formation of inositol phosphates (IPs). Increase in all of the three IPs (IP1, IP2 and IP3) could be detected 20 s after stimulation. The depletion of Ca2+ from the medium resulted in more than 80% reduction in beta-hexosaminidase release from either thrombin or IgE antigen stimulated cells. However, both thrombin and IgE antigen increased the formation of IP3 under these conditions independent of the presence of extracellular Ca2+.
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