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The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence |
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| Authors: | Peter P. Sayeski Andrew J. Paterson Jeffrey E. Kudlow |
| Affiliation: | Departments of Medicine and Physiology, Division of Endocrinology and Metabolism, University of Alabama at Birmingham, Birmingham, AL35294, USA |
| Abstract: | Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme in hexosamine synthesis and has been implicated in the control of growth factor gene expression. We cloned a mouse cDNA which is 91% homologous to the human sequence. The deduced amino-acid sequence shows 98.6% identity to human GFAT. The cDNA is derived from a 7-kb mRNA in the mouse, while there are multiple-sized human mRNAs. |
| Keywords: | Comparison with human GFAT growth factor glucosamine |
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