| HCMV大小鼠眼组织损伤模型的初步研究 |
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| 引用本文： | 孟红,孙广莲,李焱,刘菊华,王玉梅.HCMV大小鼠眼组织损伤模型的初步研究[J].中国实验动物学报,2001,9(3):150-151. |
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| 作者姓名： | 孟红 孙广莲 李焱 刘菊华 王玉梅 |
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| 作者单位： | 山东省医学科学院基础医学研究所微生物室 |
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| 基金项目： | 山东省自然科学基金资助课题(Y96C16048) |
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| 摘 要： | 目的探讨接种人巨细胞病毒(Humancytomegalovirus,HCMV)是否引起Wistar大鼠、昆明种小鼠眼组织损伤.方法将HCMVAD169毒株经静脉接种Wistar大鼠和昆明种小鼠,观察动物眼部发病情况,原位杂交检测动物眼组织中的HCMVDNA片段.结果接种病毒后部分动物缓慢出现眼部发病,局部分泌物增多、浑浊甚至失明;经原位杂交于视锥、视杆细胞和角膜内皮细胞中检出HCMVDNA片段.结论HCMV可以感染动物眼组织,并引起动物发生眼病.
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| 关 键 词： | 巨细胞病毒 感染 大鼠 小鼠 眼 动物/模型 |
| 文章编号： | 1005-4847(2001)03-0150-02 |
| 修稿时间： | 2001年2月20日 |
Study on Eye Disease of Animal Infected with HCMV AD169 Strain |
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| MENG Hong,SUN Guanglian,LI Yan,LIU Juhua,WNAG Yumei.Study on Eye Disease of Animal Infected with HCMV AD169 Strain[J].Acta Laboratorium Animalis Scientia Sinica,2001,9(3):150-151. |
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| Authors: | MENG Hong SUN Guanglian LI Yan LIU Juhua WNAG Yumei |
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| Abstract: | Objective To investigate whether HCMV infection can cause ocular tissue lesions in rats and mice.Methods Twenty rats and ten mice were inoculated with HCMV AD 169 strain by vein and development of ocular disease was observed.HCMV DNA of tissues from inoculated animals were examined by in situ hybridization.Results Some animals expressed much secretion,turbidity in eyes even losing sight at different time post\|inoculation.HCMV DNA sections were identified in the corneal endothelium cell,rod cell and cone cell of the rats and mice inoculated. Conclusion HCMV AD 169 strain can infect rats and mice and cause ocular disease. |
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| Keywords: | Cytomegalovirus Infection Rats Mice Eye Animals/models |
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