The voltage-dependent Na+ channel of insect nervous system identified by receptor sites for tetrodotoxin, and scorpion and sea anemone toxins |
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| Authors: | D Pauron J Barhanin M Lazdunski |
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| Affiliation: | 1. Harvard Medical School, Boston, MA;2. Center for Surgery and Public Health, Brigham and Women''s Hospital, Harvard Medical School, and Harvard T.H. Chan School of Public Health, Boston, MA;3. Division of Trauma, Burns, and Surgical Critical Care, Department of Surgery, Brigham and Women''s Hospital, Boston, MA;4. Department of Surgery, Boston Children''s Hospital, Boston, MA;5. Uniformed Services University of the Health Sciences, Bethesda, MD |
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| Abstract: | Receptor sites for some of the most important toxins known to be specific for voltage-sensitive Na+ channel in the mammalian nervous system have been identified in a purified membrane preparation of house fly brain. Very high affinities have been found for the association of tetrodotoxin or tetrodotoxin derivatives with the insect Na+ channel (Kd = 0.03 - 0.08 nM). The gamma toxin from the Brazilian scorpion Tityus serrulatus forms a complex with the Na+ channel having a Kd of 6.1 pM. The Kd value for toxin II from the sea anemone Anemonia sulcata is 0.12 microM. These results show a high degree of conservation of the pharmacological properties of the brain Na+ channels between insects and mammals. |
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