血清Hmga1、M-CSF及AFP与宫颈癌患者肿瘤病理特征及预后的关系

摘要 目的：探讨血清Hmga1、M-CSF、AFP与宫颈癌患者肿瘤病理特征及预后的关系。方法：选择2019年8月到2020年6月在本院妇产科诊治的120例宫颈癌患者作为宫颈癌组，同期选择宫颈良性病变患者120例作为良性组。检测两组患者的血清高迁移率族蛋白A1（Hmga1）、巨噬细胞集落刺激因子（M-CSF）、甲胎蛋白（AFP）含量，调查宫颈癌患者的肿瘤病理特征、预后情况并进行相关性分析。结果：宫颈癌组的血清Hmga1、M-CSF、AFP含量高于良性组（P<0.05）。在宫颈癌患者中，不同组织学分化、临床分期、淋巴结转移患者的血清Hmga1、M-CSF、AFP含量对比有差异（P<0.05）；随访到2022年1月1日，平均随访时间17.28±1.25个月，死亡18例，死亡率为15.0 %。Spearsman分析显示：患者预后死亡与Hmga1、M-CSF、AFP等存在相关性（P<0.05）。Cox比例风险模型分析显示Hmga1、M-CSF、AFP为影响患者预后死亡的重要因素（P<0.05）。结论：宫颈癌患者多存在血清Hmga1、M-CSF、AFP的高表达，且与患者的肿瘤病理特征存在相关性，宫颈癌患者的预后与血清Hmga1、M-CSF、AFP表达存在相关性，预测宫颈癌患者死亡具有很好的价值。

The Relationship between Serum Hmga1, M-CSF and AFP and Pathological Features and Prognosis of Cervical Cancer Patients

ABSTRACT Objective: To investigate the relationship between serum Hmga1, M-CSF, AFP and pathological features and prognosis of cervical cancer patients. Methods: From August 2019 to June 2020, 120 cases of patients with cervical cancer who were diagnosed and treated in the obstetrics and gynecology department of our hospital were selected as the cervical cancer group, and the other 120 cases of patients with benign cervical lesions were selected as the benign group during the same period. The serum high mobility group protein A1 (Hmga1), macrophage colony-stimulating factor (M-CSF) and alpha-fetoprotein (AFP) were detected in the two groups of patients. The tumor pathological characteristics and prognosis of cervical cancer patients were investigated and correlation analysis were carried out. Results: The levels of serum Hmga1, M-CSF, AFP in the cervical cancer group were higher than those in the benign group (P<0.05). In the cervical cancer patients, there were significant differences in serum Hmga1, M-CSF, AFP levels in patients with different histological differentiation, clinical stages, and lymph node metastasis (P<0.05). Followed-up until January 1, 2022, with the average follow-up time were 17.28±1.25 months, there were 18 patients were died, and the mortality rate were 15.0 %. Spearsman analysis showed that the prognosis and death of patients were correlated with Hmga1, M-CSF, AFP, etc. (P<0.05). Cox proportional hazards model analysis showed that Hmga1, M-CSF, AFP were important factors affected the prognosis and death of patients (P<0.05). Conclusion: Cervical cancer patients often have high expression of serum Hmga1, M-CSF, AFP, and they are correlated with the tumor pathological characteristics of patients. The prognosis of cervical cancer patients are correlated with serum Hmga1, M-CSF, AFP expressions. they have good values in predicting death in cervical cancer patients.