Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection |
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| Authors: | Armin Buss Katrin Pech Susanne Roelver Brunhilde Bloemeke Christoph Klotzsch Sebastian Breuer |
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| Institution: | (1) Department of Neurology, Aachen University Medical School, Pauwelsstrasse 30, Aachen, Germany;(2) Department of Ecotoxicology and Toxicology, University of Trier, Am Wissenschaftspark 27-29, Trier, Germany;(3) Department of Neurology, Schmieder-Kliniken, Zum Tafelholz 8, Allensbach, Germany |
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| Abstract: | Background Cervical artery dissection is a leading cause of cerebral ischemia in young adults. Morphological investigations have shown
alterations in the extracellular matrix (ECM) of affected vessel walls. As matrix metalloproteinases (MMP) play a central
role in the regulation of the ECM, an increased expression of these enzymes might lead to the endothelial damage in spontaneous
cervical artery dissection (sCAD). Five different DNA polymorphisms in MMP-1, -3, -9 and -12 were tested for their frequency
in patients with sCAD and compared with those of a control population. |
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