Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K. |
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| Authors: | K J Duffy L H Ridgers R L DesJarlais T A Tomaszek M J Bossard S K Thompson R M Keenan D F Veber |
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| Institution: | Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19246, USA. |
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| Abstract: | The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed. |
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